Protein Details: 5-hydroxytryptamine receptor 3A

Protein ID

ICDB_Pro_0427

Protein Name

5-hydroxytryptamine receptor 3A

Gene Name

Htr3a; 5ht3; Htr3

Organism

Mus musculus (Mouse)

Length

489 amino acids

AlphaFoldDB

AF-P23979-F1-model_v4.pdb

Function

Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes; which when activated cause fast; depolarizing responses in neurons.

Sequence

MRLCIPQVLLALFLSMLTAPGEGSRRRATQARDTTQPALLRLSDHLLANYKKGVRPVRDWRKPTTVSIDVIMYAILNVDEKNQVLTTYIWYRQYWTDEFLQWTPEDFDNVTKLSIPTDSIWVPDILINEFVDVGKSPNIPYVYVHHRGEVQNYKPLQLVTACSLDIYNFPFDVQNCSLTFTSWLHTIQDINITLWRSPEEVRSDKSIFINQGEWELLEVFPQFKEFSIDISNSYAEMKFYVIIRRRPLFYAVSLLLPSIFLMVVDIVGFCLPPDSGERVSFKITLLLGYSVFLIIVSDTLPATAIGTPLIGVYFVVCMALLVISLAETIFIVRLVHKQDLQRPVPDWLRHLVLDRIAWILCLGEQPMAHRPPATFQANKTDDCSGSDLLPAMGNHCSHVGGPQDLEKTPRGRGSPLPPPREASLAVRGLLQELSSIRHFLEKRDEMREVARDWLRVGYVLDRLLFRIYLLAVLAYSITLVTLWSIWHYS

PDB Structures

4PIR 6BE1 6DG7 6DG8 6HIN 6HIO 6HIQ 6NP0 6W1J 6W1M 6W1Y 6Y1Z

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Brain; spinal cord; and heart

DOI ID

10.1126/science.1718042; 10.1016/0014-5793(94)80435-4; 10.1016/0922-4106(93)90128-v; 10.1016/0169-328x(94)90095-7; 10.1371/journal.pbio.1000112; 10.1038/nature13552

RefSeq

NP_038589.2 [P23979-1]